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Marijuana MSO’s are cannabis companies that focus on operations within multiple states. Multi-State Operators or “MSOs” A number of pot stocks to buy and watch have targeted the MSO model and for good reason. With the cannabis industry slated to generate revenue in the tens of billions of dollars over the next decade, it stands to reason that MSO pot stocks are a must on any watch list. What Is A MSO? Multi-state operators are cannabis companies that have a reach across multiple legal cannabis states. In comparison to single-state operators own cultivation facilities, extraction/processing facilities, and cannabis retail operations in some of the most highly populated states across the US with laws in place legalizing recreational or medical cannabis.